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CARDIOTOXICITY OF POLYCYCLIC AROMATIC HYDROCARBONS (PAHs)
Air pollution is associated with a range of adverse cardiovascular events including heart attacks, strokes, and irregular heart rhythms, particularly in people already at risk for these conditions. The mechanisms of air pollution based cardiotoxicity are complex and can be attributed in part, to nanoparticles containing aromatic hydrocarbons (PAHs). The aim of this project is to determine the mechanisms by which PAHs induce cellular cardiac dysfunction in hiPSC derived cardiomyocytes and in freshly isolated zebrafish cardiomyocytes. Experience in cellular cardiology including single cell electrophysiology and ion imaging are essential skills. The PDRA will be responsible for data analysis, writing up the findings and disseminating them in conjunction with supervisors and collaborators situated in Bristol and France.
The majority of the research will conducted in Manchester but with collaborative projects in Bristol and France.
Successful candidates may be subject to pre-employment screening carried out on our behalf by a third party. The offer of employment will be dependent on the successful candidate passing that screening. Whilst you will be required to provide express consent at a later stage, by continuing with your application now you acknowledge that you are aware that such screening will take place, and agree to take part in the process.
The School is committed to promoting equality and diversity, including the Athena SWAN charter for promoting women’s careers in STEMM subjects (science, technology, engineering, mathematics and medicine) in higher education. The School holds a Bronze Award for their commitment to the representation of women in the workplace and we particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit: https://www.bmh.manchester.ac.uk/about/equality/
Please note that we are unable to respond to enquiries, accept CVs or applications from Recruitment Agencies
Enquiries about the vacancy, shortlisting and interviews:
Name: Dr Holly Shiels
Tel: 0161 275 5092
Tel: 0161 275 4499
Tel: 0161 850 2004
This vacancy will close for applications at midnight on the closing date
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